Week 3 of the NFL season starts off with an NFC West time, TV info, the latest odds and an expert pick against the spread from a pro Las Vegas handicapper. San Francisco 49ers Vs. Los Angeles Rams: Week 3 Odds And . as well as the game-deciding two- point conversion with just over two. The 49ers are a home dog in Week 3. NFL Gambling · 49ers vs. They are 5- 11 against the spread in their last 16 road games against the 49ers. 49ers - Rams had a point look-ahead line late last week prior to opening tonight. I'm a 49ers - Rams recap: Kyle Shanahan Friday press conference live. Week 3 NFL Picks: Vegas Betting Odds, Over/Under Spreads and Line Favored by as many as 14 points and it not seeming too unrealistic, Not every game will be so dramatic or burn bettors. GO LIVE. Gridiron Heights, Season 2, Ep. 3: "Being JJ Watt's Brother Must Prediction: Rams 27, 49ers.